abstract：BACKGROUND:Galectin-3 is a lectin that presents pivotal roles in tumor biology and there are no studies evaluating their expression in dysplasias and carcinomas developed from tongue carcinogenesis models. AIMS:To investigate the role of galectin-3 in the development of tongue carcinomas using a mouse model of oral ca...

journal_title：Experimental and molecular pathology

authors： de Faria PR,Chammas R,de Melo TL,Hsu DK,Liu FT,Nonogaki S,Cardoso SV,Loyola AM

更新日期：2011-04-01 00:00:00

abstract：:The most common recurrent translocation in clear cell sarcoma t(12;22)(q13;q12) results in an EWSR1/ATF1 chimeric gene. We present a molecular analysis of tumor overgrowing right proximal tibia with bone destruction metastatic to two groin lymph nodes. Fluorescent in situ hybridization analysis performed on paraffin-e...

journal_title：Experimental and molecular pathology

authors： Jakubauskas A,Valceckiene V,Andrekute K,Seinin D,Kanopka A,Griskevicius L

更新日期：2011-04-01 00:00:00

abstract：:In the treatment of breast cancer, although a wide of choice of drugs and treatment modalities are available, drug resistance or drug toxicity poses a considerable challenge. Tranilast is a well tolerated drug used in the treatment of allergic disorders. Previous works in various models have shown that tranilast has t...

journal_title：Experimental and molecular pathology

authors： Subramaniam V,Ace O,Prud'homme GJ,Jothy S

更新日期：2011-02-01 00:00:00

abstract：:Retinoblastoma (RB), the most common intra-ocular malignancy in children under 5 years of age, has an estimated incidence of about 2000 a year in India, where most cases are in advanced stage at the time of diagnosis. Newer therapeutic approaches would reduce the morbidity of chemotherapy in children with RB. Fatty Ac...

journal_title：Experimental and molecular pathology

authors： Vandhana S,Deepa PR,Jayanthi U,Biswas J,Krishnakumar S

更新日期：2011-02-01 00:00:00

abstract：:Plasmablastic lymphoma (PBL) is an uncommon aggressive lymphoma arising most frequently in the oral cavity of HIV-infected patients. Rare cases of PBL have been reported in extraoral sites, particularly extranodal sites, as well as in immunocompetent patients. We report an unusual case of PBL in a 69-year-old, HIV-neg...

journal_title：Experimental and molecular pathology

authors： Qing X,Sun N,Chang E,French S,Ji P,Yue C

更新日期：2011-02-01 00:00:00

abstract：:In our previous study, we demonstrated that a peptide derived from the novel centrosome residing protein Cep55/c10orf3 can be targeted by the cytotoxic T lymphocytes (CTLs) in peripheral blood mononuclear cells (PBMCs) of breast carcinoma patients. In this report, we evaluated the feasibility of cancer immunotherapy u...

journal_title：Experimental and molecular pathology

authors： Inoda S,Morita R,Hirohashi Y,Torigoe T,Asanuma H,Nakazawa E,Nakatsugawa M,Tamura Y,Kamiguchi K,Tsuruma T,Terui T,Ishitani K,Hashino S,Wang Q,Greene MI,Hasegawa T,Hirata K,Asaka M,Sato N

更新日期：2011-02-01 00:00:00

abstract：:In the present study, BALB/c mice were used to develop a model for the hepatic injury associated to dengue infection. Histological analysis after subcutaneous inoculation with a low viral dose of dengue-2 virus showed Kupffer cell hyperplasia and an increased inflammatory cellular infiltrate next to the bile ducts on ...

journal_title：Experimental and molecular pathology

authors： França RF,Zucoloto S,da Fonseca BA

更新日期：2010-12-01 00:00:00

abstract：:Previously, we described an orthotopic cholangiocarcinoma model based on bile duct inoculation of spontaneously-transformed low grade malignant rat BDE1 cholangiocytes (BDEsp cells) compared to high grade malignant erbB-2/neu- transformed BDE1 cholangiocytes (BDEneu cells) into the livers of syngeneic rats, which clos...

journal_title：Experimental and molecular pathology

authors： Dumur CI,Campbell DJ,DeWitt JL,Oyesanya RA,Sirica AE

更新日期：2010-12-01 00:00:00

abstract：:SNAIL, a potent repressor of E-cadherin expression, plays a key role in inducing epithelial-to-mesenchymal transition (EMT) in epithelial cells. During EMT, epithelial cells lose cell polarity and adhesion, and undergo drastic morphological changes acquiring highly migratory abilities. Although there is increasing evi...

journal_title：Experimental and molecular pathology

authors： Nishioka R,Itoh S,Gui T,Gai Z,Oikawa K,Kawai M,Tani M,Yamaue H,Muragaki Y

更新日期：2010-10-01 00:00:00

abstract：:IL-12Rβ2(-/-) mice, which are unresponsive to IL-12, develop severe experimental autoimmune encephalomyelitis (EAE). The mechanisms for enhanced autoimmunity are incompletely understood. We report that in IL-12Rβ2(-/-) mice, thymocytes undergo markedly accelerated maturation. This occurs at the transition from a doubl...

journal_title：Experimental and molecular pathology

authors： Gran B,Yu S,Zhang GX,Rostami A

更新日期：2010-10-01 00:00:00

abstract：:Genes involved in the control of cell proliferation and survival (those genes most important to cancer pathogenesis) are often specifically regulated at the translational level, through RNA-protein interactions involving the 5'-untranslated region of the mRNA. IGF1R is a proto-oncogene strongly implicated in human bre...

journal_title：Experimental and molecular pathology

authors： Blume SW,Jackson NL,Frost AR,Grizzle WE,Shcherbakov OD,Choi H,Meng Z

更新日期：2010-06-01 00:00:00

abstract：:Lumican is a member of a small leucine-rich proteoglycan (SLRP) family and it regulates the assembly and diameter of collagen fibers in the extracellular matrix of various tissues. Lumican expression was reported in various kinds of tumor cells. Lumican inhibits the growth of melanoma cells, but the lumican in pancrea...

journal_title：Experimental and molecular pathology

authors： Ishiwata T,Yamamoto T,Kawahara K,Kawamoto Y,Matsuda Y,Ishiwata S,Naito Z

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMSCs) could differentiate into cardiomyocytes. In this study, we wished to determine whether we could improve ventricular function in a dilated cardiomyopathy (DCM) model in the rabbit by injecting stem cells directly into the ventricular wall. METHODS AND RESULTS:Japane...

journal_title：Experimental and molecular pathology

authors： Chen Y,Liu W,Li W,Gao C

更新日期：2010-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth most common cancer and the fourth leading cause of cancer mortality globally. HCC incidence has doubled in Egypt in the past 10 years, which could be attributed to the high prevalence of hepatitis C virus (HCV) and hepatitis B virus (HBV), although HBV rates have declined af...

journal_title：Experimental and molecular pathology

authors： Iyer P,Zekri AR,Hung CW,Schiefelbein E,Ismail K,Hablas A,Seifeldin IA,Soliman AS

更新日期：2010-02-01 00:00:00

abstract：:While the EGFR and most of its ligands are expressed in the male reproductive tract, their functions in male reproduction are poorly understood. Interestingly, male transgenic mice overexpressing EGF are sterile, and transgenic mice overexpressing TGFA, another EGFR ligand, show an enlarged coagulation gland (anterior...

journal_title：Experimental and molecular pathology

authors： Schneider MR,Gratao AA,Dahlhoff M,Boersma A,Hrabé de Angelis M,Hoang-Vu C,Wolf E,Klonisch T

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:This study was designed to investigate whether IL-17 can regulate the expression of the MMP/TIMP system, the OPG/RANK/RANKL system, or type-I and type-III collagen fibers in a rat model of isoproterenol-induced heart failure (HF). We also investigated the effect of IL-17 on myocardial fibrosis in this model. ...

journal_title：Experimental and molecular pathology

authors： Feng W,Li W,Liu W,Wang F,Li Y,Yan W

更新日期：2009-12-01 00:00:00

abstract：:Several studies recognize cancer-stromal fibroblasts' role in cancer-cell invasion and metastasis. Through paracrine signaling molecules, TGF-beta and IL-1beta, cancer cells activate stromal fibroblasts and induce the expression of fibroblast activation protein (FAP). FAP, in turn, affects the proliferation, invasion ...

journal_title：Experimental and molecular pathology

authors： Chen H,Yang WW,Wen QT,Xu L,Chen M

更新日期：2009-12-01 00:00:00

abstract：:A novel intrauterine transplantation (IUT) approach was developed to improve the efficiency of engraftment of hematopoietic stem cells (HSCs). HSCs with a green fluorescent protein (GFP) reporter gene were transplanted in utero on days 12.5, 13.5 and 14.5 post coitum (p.c.). The degree of chimerism of donor cells in r...

journal_title：Experimental and molecular pathology

authors： Chen X,Gong XL,Katsumata M,Zeng YT,Huang SZ,Zeng F

更新日期：2009-12-01 00:00:00

abstract：:Eotaxin/CCL11 chemokine is expressed in different organs, including the heart, but its precise cellular origin in the heart is unknown. Eotaxin is associated with Th2-like responses and exerts its chemotactic effect through the chemokine receptor-3 (CCR3), which is also expressed on mast cells (MC). The aim of our stu...

journal_title：Experimental and molecular pathology

authors： Zweifel M,Mueller C,Schaffner T,Dahinden C,Matozan K,Driscoll R,Mohacsi P

更新日期：2009-10-01 00:00:00

abstract：:We investigated the protein carbonylation of red blood cell (RBC) membrane in type 2 diabetic patients and the potential implication of carbonyl/oxidative stress in reflecting disease severity. Sixty-four diabetic patients with or without retinopathy of variable clinical severity (Groups DR and DM, respectively) and 2...

journal_title：Experimental and molecular pathology

authors： Margetis PI,Antonelou MH,Petropoulos IK,Margaritis LH,Papassideri IS

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the role and regulatory mechanisms of Akt/TSC1-TSC2/mTOR signal pathway on the hepatocyte growth and proliferation after partial hepatectomy in rats. METHODS:We used the animal model of 70% hepatectomy, separated and cultivated hepatocytes. According to the different ...

journal_title：Experimental and molecular pathology

authors： Chen P,Yan H,Chen Y,He Z

更新日期：2009-04-01 00:00:00

abstract：:Host immune status is an important determinant of disease progression. Infections in the genital tract may alter the immunity in the particular site and hence affect the production of local cytokines. We performed this study to determine whether HIV in association with cervical HPV and CT/GC infections influences the ...

journal_title：Experimental and molecular pathology

authors： Guha D,Chatterjee R

更新日期：2009-02-01 00:00:00

abstract：:To investigate whether aberrant hypermethylation in plasma DNA could be used as diagnosis makers for hepatocellular carcinoma (HCC), we performed methylation-specific PCR (MSP) to check the methylation status of five tumor associated genes in 36 cases of tissue and 42 cases of plasma samples from HCC and liver cirrhos...

journal_title：Experimental and molecular pathology

authors： Chang H,Yi B,Li L,Zhang HY,Sun F,Dong SQ,Cao Y

更新日期：2008-10-01 00:00:00

abstract：:Severe sepsis remains an important cause of death, particularly among trauma and burn patients. The severity of the systemic inflammatory response after trauma or burns and susceptibility to sepsis vary among individuals. One possible mechanism is through differential effects on glucocorticoid receptor (GR) expression...

journal_title：Experimental and molecular pathology

authors： Yee KS,Cho K,Green T,Chandler J,Greenhalgh DG

更新日期：2008-06-01 00:00:00

abstract：:To understand the contribution of IL-6/IL-6R to subchondral bone and bone marrow abnormality in RA patients and the effects of tocilizumab on those abnormalities, we evaluated early change in a collagen-induced arthritis (CIA) monkey model with or without a single administration of tocilizumab. Six CIA cynomolgus monk...

journal_title：Experimental and molecular pathology

authors： Kato A,Matsuo S,Takai H,Uchiyama Y,Mihara M,Suzuki M

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Inhibition of the nuclear enzyme poly ribose synthetase (PARS) protects against in vivo lung ischemia reperfusion injury (LIRI). The effectiveness of intratracheal treatment suggests that PARS inhibition may primarily modulate alveolar macrophage (AM) activation. These studies attempted to characterize the e...

journal_title：Experimental and molecular pathology

authors： McCourtie AS,Farivar AS,Woolley SM,Merry HE,Wolf PS,Szabo C,Mulligan MS

更新日期：2008-04-01 00:00:00

abstract：:The keratinocyte growth factor (KGF) regulates cell growth and behavior in an autocrine or paracrine manner. In colorectal cancer tissues, KGF is expressed in tumor cells and adjacent stromal fibroblasts. We have constructed a KGF-gene-transfected cell line (HCT15-KGF) from a colorectal cancer cell line, HCT-15, that ...

journal_title：Experimental and molecular pathology

authors： Kudo M,Ishiwata T,Nakazawa N,Kawahara K,Fujii T,Teduka K,Naito Z

更新日期：2007-12-01 00:00:00

abstract：:The MHB-2 cell line, established from a mouse hepatoblastoma (HB), was subjected to the reverse transcriptase-polymerase chain reaction (RT-PCR) for evaluation of gene expression related to cell differentiation. RNAs for c-kit, CD34, thy-1, albumin, cytokeratin (CK) 8, 18 and 19 could be detected, but expression of al...

journal_title：Experimental and molecular pathology

authors： Sakairi T,Okada M,Ikeda I,Utsumi H,Kohge S,Sugimoto J,Sano F,Takagi S

更新日期：2007-12-01 00:00:00

abstract：:The present study was aimed at clarifying the effects of an anti-apoptotic protein for modulating symptoms in acute lung injury (ALI). From Bcl-x(L), a Bcl-2 family member, we constructed an artificial protein (FNK) and fused it with the protein transduction domain (PTD) of the HIV/Tat protein (PTD-FNK) to facilitate ...

journal_title：Experimental and molecular pathology

authors： Chen H,Zhang L,Jin Z,Jin E,Fujiwara M,Ghazizadeh M,Asoh S,Ohta S,Kawanami O

更新日期：2007-12-01 00:00:00

abstract：:Abnormalities in several signaling pathways and in the expression and/or activation of different transcription factors in psoriatic keratinocytes have been hypothesized to play a role in the pathophysiology of psoriasis. The mitogen-activated protein kinase (MAPK) cascades are among the best characterized of intracell...

journal_title：Experimental and molecular pathology

authors： Yu XJ,Li CY,Dai HY,Cai DX,Wang KY,Xu YH,Chen LM,Zhou CL

更新日期：2007-12-01 00:00:00

abstract：:Platelet homeostasis reflects a balance between the production of platelets via cytoplasmic fragmentation of megakaryocytes in the pulmonary microvasculature and their catabolism. Increased numbers of megakaryocytes are entrapped in the injured lung, potentially affecting circulating platelet counts. We enumerated pul...

journal_title：Experimental and molecular pathology

authors： Mandal RV,Mark EJ,Kradin RL

更新日期：2007-12-01 00:00:00

abstract：:Ischemia has elicited a great deal of interest among the scientific community due to its role in life-threatening pathologies such as cancer, stroke, acute renal failure, and myocardial infarction. Oxygen deprivation (hypoxia) associated with ischemia has recently become a subject of intense scrutiny. New investigator...

journal_title：Experimental and molecular pathology

authors： Russ AL,Haberstroh KM,Rundell AE

更新日期：2007-10-01 00:00:00

abstract：:We have analyzed the localization of dendritic cells (DCs) in non-lesional gray matter (NLGM) in comparison to non-lesional white matter (NLWM) and acute or chronic active multiple sclerosis (MS) lesions. Immunohistochemistry was performed on cryostat sections for DCs markers (CD209, CD205, CD83) and other markers for...

journal_title：Experimental and molecular pathology

authors： Cudrici C,Ito T,Zafranskaia E,Niculescu F,Mullen KM,Vlaicu S,Judge SI,Calabresi PA,Rus H

更新日期：2007-10-01 00:00:00

abstract：:Dendritic cells (DCs) are a subset of antigen-presenting cells (APCs) that are involved in the initiation and control of the immune response to antigens present at the interface with the environment. A limited number of groups have studied DCs in human and animal conjunctiva but no data is available concerning the dif...

journal_title：Experimental and molecular pathology

authors： Ohbayashi M,Manzouri B,Flynn T,Toda M,Ikeda Y,Nakamura T,Ono SJ

更新日期：2007-10-01 00:00:00

abstract：:Since the first mitochondrial dysfunction was described in the 1960s, the medicine has advanced in its understanding the role mitochondria play in health, disease, and aging. A wide range of seemingly unrelated disorders, such as schizophrenia, bipolar disease, dementia, Alzheimer's disease, epilepsy, migraine headach...

journal_title：Experimental and molecular pathology

authors： Pieczenik SR,Neustadt J

更新日期：2007-08-01 00:00:00

abstract：:Knowledge of the factors regulating the rate of mRNA degradation, including postmortem delay, is important in determining the reliability of gene expression patterns in dermal tissue. Since RNA stability can be tissue dependent, this study evaluates the effect of postmortem interval on the integrity of total RNA or th...

journal_title：Experimental and molecular pathology

authors： Gopee NV,Howard PC

更新日期：2007-08-01 00:00:00

abstract：:The presence of immune cells is important for plaque destabilization. Disturbed flow conditions were shown to enhance the recruitment of circulating immune cells. Thus, we analyzed in 54 atherosclerotic carotid plaques the frequency of different immune cells, HLA-DR, chemokines, and chemokine receptors, comparing the ...

journal_title：Experimental and molecular pathology

authors： Yilmaz A,Lipfert B,Cicha I,Schubert K,Klein M,Raithel D,Daniel WG,Garlichs CD

更新日期：2007-06-01 00:00:00

abstract：:In this paper, we report on phosphorescence measurements for oxygen dynamics in cells by means of a correlation method, which is an expansion of the fluorescence correlation spectroscopy. The intensity correlation function of the emission excited by a pulsed light source was measured. With changing the pulse timing, b...

journal_title：Experimental and molecular pathology

authors： Nishimura G,Pack CG,Tamura M

更新日期：2007-04-01 00:00:00

abstract：:The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 eth...

journal_title：Experimental and molecular pathology

authors： Rodríguez-Pérez JM,Fragoso JM,Alvarez-León E,Martínez-Rodríguez N,Gallardo GJ,Inés-Real S,Granados J,Reyes PA,Vargas-Alarcón G

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:The increased expression of the fibroblast growth factor receptor 4 (FGFR4) has been identified in many human cancers. Recently, a single nucleotide polymorphism changing the sense codon 388 from glycine to arginine was identified in the FGFR4 gene. The FGFR4 Arg(388) allele was found to be associated with a...

journal_title：Experimental and molecular pathology

authors： da Costa Andrade VC,Parise O Jr,Hors CP,de Melo Martins PC,Silva AP,Garicochea B

更新日期：2007-02-01 00:00:00